leptin

Hoping to understand obesity, brain researchers continued to hunt for molecules that, like leptin, control food intake.

Whether or not infant formula with leptin should be classified as a food or medicine was a question that would have to be resolved, he said.

Researchers originally thought leptin signaled the body to stop eating and hoped that it might be harnessed as a weight-loss drug.

However, leptin did not turn out to be the amazing cure-all for which scientists, physicians, and patients had hoped.

The system used to work like a charm. But these days, I churn out leptin like it's going out of style and his brain doesn't get the message.

Among the hormones that fuel these urges are ghrelin and leptin, known as the "hunger hormones. "

It is thought that leptin, in an attempt to balance energy levels in the body, could trigger SPARC to limit the storage of fat.

Results There was no significant difference in the level of leptin of the cirrhotic patients and the controls.

The research in rats supplemented with leptin is in its very early stages and needs to be replicated by further studies.

If you could get a clever leptin agonist molecule then there is of course huge potential for the treatment.

That insulin spike also interferes with leptin, the hormone secreted by fat cells that should tell the body to stop eating.

Objective To understand change of microalbuminuria in adiposity and pathogenesis of leptin.

Leptin receptor deficient mice do not know the feeling of fullness.

Leptin is naturally produced throughout life. But the research suggests that in infancy it "hardwires" the body's energy balance settings.

Objective To understand the levels of microalbuminuria and leptin in obese children.

Does this finding mean that leptin levels do not contribute to anorexia, but result from malnutrition?

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ.

Probably on the base of this mechanism leptin acts as a link between metabolic state and reproductive system.

In humans elevated leptin levels are associated with a greater risk of some cancers, including melanoma, breast and prostate malignancies.

Immunohistochemical staining was used to detect leptin expression in placenta.

Leptin was firstly considered as a protein secreted by adipose cells. Leptin can inhibit appetite and increase energy consumption.

In addition to its central actions, leptin exerts biological effects by acting in peripheral tissues including the endocrine pancreas.

OBJECTIVE To explore into the relationship between fat distribution and leptin and insulin in Acupuncture treatment for reducing weight.

Not having enough sleep decreases the levels of leptin in our blood, which means we do not feel as satisfied after eating.

We found that the local administration of leptin into the area inhibited the inspiratory-terminating Breuer-Hering reflex.

Conclusion: CAPD patients have hypoalbuminemia and hyperleptinemia. Leptin can be partly cleared by peritoneal dialysis.

To date, leptin has proved to be a great disappointment.

Without neurons reacting to the blood leptin level, the brain does not control the feeling of hunger and fullness.

Too much ghrelin and too little leptin have been shown to result in a larger appetite.

Leptin decreases food intake; ghrelin and the endocannabinoids increase it (see Peptides May Be Treatment Targets).

Leptin, which exercises an influence on appetite andthermogenesis, is thought to be key to maintaining this balance.

Objective: To observe the expression, distribution and development of leptin and its receptor in fetal submandibular glands.

Leptin, the production of the ob gene, plays an important role in the regulation of energy homeostasis.

Leptin, a pleiotrophic hormone mainly synthesized by adipocytes, is an important signaling molecule in energy regulation and food intake.

Leptin also acts on cell bodies, which express cocaine and amphetamine regulated transcript (CART), another anorectic peptide.

Leptin is a natural appetite suppressant secreted by fat cells in the body.

Objective: To explore the relationship between serum leptin, hypertension and relevant factors in elderly persons.

The scientists then traced the leptin decline to a pathway that originates in the brain's hypothalamus.

Th is paper reviewed concerning researches and progress in research on relationship of leptin with obesity and puberty development.

In this article some informations about leptin secretion, its regulation and localization of leptin receptors have been presented.

Leptin, a circulating peptide hormone produced by adipocytes, regulates body weight by effects on food intake and metabolism.

Data confirmed that leptin can promote the role of atherosclerosis, and adiponectin can oppose atherosclerosis.

Anti-inflammatory and anti-remodeling of inhaled corticosteroids were not by the way of leptin and adiponectin.

Leptin is related to obesity and insulin metabolism, so its action in pathogenesis of polycystic ovary syndrome have been concerned.

CONCLUSIONS: The association between leptin and incident diabetes is mediated by insulin resistance.

Objective To analyze the relationship between serum leptin concentration and simple obesity of teenagers.

The relationship between serum leptin levels and insulin resistance in hypertensive and obesity patients.

Conclusion The increased serum levels of leptin correlates to the metabolism disorders of serum lipids in PIH patients.

Objective to explore the relationship between serum leptin level and amenorrhoea, infertility.

Leptin improved animal body weight recovery and behavioral parameters after cerebral ischemia.

Objective To find the relationship between serum leptin concentration and malnutrition in gastric cancer patients.

Insulin resistance and leptin levels are positively correlated with body mass index and duration of valproate therapy.

To determine plasma leptin concentration with RIA, to determine plasma glucose, lipid, body height and body mass in 171 subjects.

Some data about leptin secretion in obesity, weight loss related amenorrhoea and anorexia nervosa have been discussed.

Leptin is a secretory protein encoded by obese gene, which plays role in regulating weight, fat and energy metabolisms.

Comments on "The relationship between expressions of OB-Ra and OB-Rb mRNA in liver and serum leptin level in SD rats fed with high fat diet"

Leptin, which suppresses appetite, is lowered; ghrelin, which stimulates appetite, gets a boost.

The soluble leptin receptor concentrations of the female psoriasis patients were significantly lower than the normal female controls (p05).

Leptin, a peptide secreted from adipose tissue, plays an important role in the regulation of food intake and energy expenditure.

Because humans also produce leptin, researchers hoped giving the hormone to obese people would result in weight loss.

AbstractObjectiveTo investigate the effects of valproate treatment on plasma insulin and leptin levels of epileptic children.

Serum levels of adiponectin and leptin were measured by RIA (radiological immunological assay).

Status Offline MC-4 is the neural gateway for ghrelin, leptin and up to 20 other chemicals.

The oscillating pattern varies in different organs and determines the effect of leptin on regulation of the energy balance.

Adiponectin and leptin are both adipocytokine secreted by the Adipose tissue.

It is secreted from fat tissue in direct proportion to the amount of total fat mass: the fatter a child, the more Leptin they produce.

As a kind of peptide hormone secreted by fatty tissue, leptin play its role in regulating body weight by combining with leptin receptor.

Objective To observe the distribution of leptin and its receptor in jejunum and ileum on 22 fetuses of different age.

There were positive correlations between insulin resistance and leptin levels.

Obese people have been found to have an abnormally high level of leptin in their bloodstream.

Leptin is a protein secreted from cells of the fat tissue into the blood when eating.

One explanation involves the hormones leptin and ghrelin, which regulate appetite.

Leptin has several roles, but one is to encourage cells to oxidise lipids and thus destroy them.

The hypothalamus is the primary brain region that responds to leptin, sending a signal that curbs appetite.

If you skimp on sleep, ghrelin levels rise, making you hungry, and leptin levels dip, which signals a need for calories.

Figuring out how to use leptin to help humans struggling with obesity has proven elusive.

Leptin decides whether fat should be stored or used, resulting in lethargy or energy.

Yet many questions about the roles of leptin, ghrelin, and the endocannabinoids in obesity and eating disorders press for answers.

The decrease in serum leptin levels was not correlated with the changes in the others.

Maas blames two hormones: leptin, which helps the brain sense when you're full, and ghrelin, which triggers hunger.

Leptin production, meanwhile, grows along with the mass of the adipose tissue.

The JAMA study builds on work that links low leptin levels to the brain plaques found in Alzheimer's patients.

In female obese students, only TG , insulin and HOMA-IR were positively correlated with serum leptin.

abstract: Objective To explore the effects of REM sleep deprivation on anxiety behavior in rats and the role of leptin.

Leptin binded its receptors could produce biological effect through signal transduction pathway.

Animal studies suggest early exposure to the hormone leptin can programme the brain to prevent over-eating throughout life.

The hormone leptin is produced by fat and helps regulate insulin secreted by pancreatic beta cells.

The key driver of this system is leptin, a hormone secreted by fat cells.

Method: The leptin values in peripheral venous and cord bloods in 62 full term pregnant women were measured by Radioimmunoassay (RIA).

The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

Objective: To investigate the possible relationship between variant of point 519 in leptin receptor(LEPR) gene and obesity.

Objective To explore the role of leptin and leptin receptor in the fertilized egg implantation.

The same group of short sleepers also had more than 15 percent less Leptin, a hormone produced by fat tissue when energy levels are low.

IntroductionLeptin derived from the Greek, also has been known as slim factor, discovered by Zhang first in 1994.

Those neurons get their message from hormones, including insulin and leptin.

Researchers soon found that in addition to leptin, a whole host of chemicals signal the brain to trigger hunger or fullness.

As that happens, hormones like ghrelin, leptin, and insulin communicate between the stomach and the brain, helping signal satiety.

Conclusions Leptin in the presence of bile in the bile of gallstone leptin involved in type 2 diabetes mellitus and gallstone disease.

Sleep has an important effect on the hormones ghrelin and leptin, which control hunger and appetite.

This article reviews leptin's pathophysiological role in prostate cancer progression.

The researchers then gave the mice leptin, a hormone that suppresses appetite, and as suspected, saw lowered AMPK levels.

ResultsSerum soluble leptin receptor and adiponectin levels were significantly lower in patients than healthy controls (p01).

The effects of exercise on plasma leptin concentrations are delayed.

Leptin expression in the control group, gallstone group and type 2 diabetes followed by gallstone group enhanced.

Objective: To explore the relationship between leptin and the occurrence of children with type 1 diabetic mellitus (DM).

Animals born of leptin-treated mothers remain lean, despite being fed a fat-laden diet.

Leptin: an independent risk factor of insulin resistance?

These hormones are called leptin and adiponectin.

They then added the leptin receptor to one small group of brain cells.

However, plasma Leptin and NPY levels of anorexia rats have little effect.

First they gave either of the two drugs to obese mice fed a high- fat diet, then injected them with leptin.

Not surprisingly, the discovery of leptin was huge news in the diet community.

Exploration of leptin in gallstones and type 2 diabetes mellitus pathogenesis of gallstones in the role.

For example, in the cases of the heart-muscle cells and pancreatic cells mentioned above, dosing them with leptin keeps them healthy.

Obese people have loads of leptin, but it either doesn't get to the brain, or the brain becomes resistant to it.

High leptin levels were significantly associated with insulin resistance, and they may play an role in coronary heart disease.

Besides ghrelin and leptin, many other hormones play a role in appetite.

They are resistant to the effects of leptin in much the same way that people with type 2 diabetes are resistant to the effects of insulin.

But it's also possible that substances produced by fat cells, such as the hormone leptin, have direct effects on the brain.

long term exercise training can reduce plasma leptin concentrations and this is due to decreased body mass.

The problem is, people who gain weight have now beenshown to develop a remarkable resistance to leptin's power.

ConclusionValproate therapy can lead to weight gain, insulin resistance and leptin resistance.

Once a critical body mass has been reached, a hormone called Leptin is produced.

And mice without leptin are sluggish balls of blubber.

High leptin levels relay the opposite signal.

Conclusion There is a gender difference in serum leptin levels in cirrhosis.

Leptin is a hormone made by fat cells that tells you when you're full.

Particular attention to leptin influence on GnRH secretion have been paid.

Measuring the level of serum leptin in chronic liver disease .

A role for circulating hormones such as adiponectin and leptin in the activation of AMPK has received recent attention.

The men also gave blood so that researchers could test for hormones linked to appetite and obesity, such as leptin and ghrelin.

Some peripheral tissues, such as trophocytes of placenta can synthesize and secrete leptin.

What is more, leptin also is a new type immune regulatory factor, which is closely related to the genesis of many immune diseases.

ObjectiveTo study the effect of Tongluo recipe on leptin and insulin in rat model of type 1 diabetes mellitus.

Their weight was reduced by 10% and they were given either replacement leptin or a placebo.

Leptin can not be a index of evaluating liver function for cirrhosis.

The fatterthey get, and the more leptin they make, the more impervious thehypothalamus becomes.

The expression level of SREBP-1 and leptin increased in HF groups.

Serum C-peptide (P05), amylin (P01), and leptin (P01), but not adiponectin nor resistin, were higher in IR.

Objective To study the expression and distribution of leptin and its re-ceptor in adult human submandibular gland.

OBJECTIVE: To study the effects of valproate acid (VPA) on serum lipid and leptin levels and cerebral cortex in juvenile and adult rats.

Objective To study the difference of serum leptin in different types of hepatic cirrhosis patients.

Objective To study the relativity of cardiac valve calcification (VC) and P-Selectin (PS), leptin in oldly patients with hemodialysis.

The gene produced a protein called leptin that is made in fat cells.

A preliminary study of the relationship between leptin and its receptor and primary hepatocellular carcinoma

Clinical study of maternal serum leptin levels as a predictor of gestational diabetes mellitus and gestational impaired glucose tolerance

Relationships of the Expression of Leptin and its Receptor between Angiogenesis, Growth and Metastasis in Human Hepatocellular Carcinoma

Study of the relation between serum leptin and malnutrition in patients with chronic obstructive pulmonary disease

Study of changes of adiponectin and leptin in hypertension disorder complicating pregnancy and their clinical significance

Relationship between serum leptin concentration and angiographic characteristics of coronary atherosclerosis

Clinical study of the nutrition and serum leptin level in maintainance hemodialysis patients of different dialysis modalities

Studies examining the effects of a single exercise session and plasma leptin have found conflicting results (no change or reduction) ;

Study of the Relationship Between Serum Leptin with Insulin Resistance in Cirrhosis

Relationship Between Serum Leptin and Proinflammatory Cytokines in Patients Undergoing Maintenance Hemodialysis

Study of serum leptin in heroin addicts and its relation with bone mineral densities

Improvement of leptin and insulin sensitivity due to early nutritional intervention in rats born with intrauterine growth retardation

Study of relationship between girls precocious puberty and serum leptin, insulin- like growth factor-1, electroencephalogram

Study on the changes of the serum leptin levels and its influential factors in patients with chronic renal failure

Study of Serum Leptin Level in Hemodialysis Patients and its Nutriture

The relationship between serum leptin concentrations and body composition, and physical fitness parameters in Hongkong prepuberty athletes

Expression of leptin receptor in colorectal adenocarcinoma and its clinical significance

The change and its clinical significance of plasma insulin sensitivity and leptin level in the patients with ischemic stroke

Relationship between Serum Leptin Level and Malnutrition in Elderly Patients Undergoing Maintenance Hemodialysis

The relationship between juvenile serum leptin levels and obesity, serum glucose as well as insulin concentrations

The relationship between serum leptin levels in IGT patients and obesity, plasma glucose as well as insulin concentrations

Relationship between leptin, insulin and hypertensive disorder complicating pregnancy

Serum leptin level and its significance in the maintenance hemodialysis patients with chronic renal failure

The Relationship between Serum Leptin Level and Malnutrition in Elderly Patients Undergoing Maintenance Peritoneal Dialysis

Clinical investigation of different blood purification techniques on clearing serum leptin of chronic hemodialysis patients

Detection and Its Significance of Serum Leptin and Ferritin in Childhood Acute Lymphoblastic Leukemia

Expression and signaling of leptin and its receptors in Helicobacter pylori-associated gastritis

The relationship between human plasma leptin levels and obesity, plasma glucose as well as insulin concentrations

Estimation of serum leptin levels in girls with idiopathic central precocious puberty and its implication

Immunohistochemical observation of the leptin and its receptor in the parotid gland of human fetus

Serum leptin concentration in patients with chronic renal failure and its clinical significance

Relationship Between Serum Leptin Level and Malnutrition in Patients Undergoing Maintenance Hemodialysis

Detection of serum leptin and its significance in female patients with systemic lupus erythematosus

Preliminary investigation of serum leptin effect on nutrition state of chronic renal failure patients

Relationship between fasting leptin levels and left ventricular hypertrophy in male patients with essential hypertension

Preparation of Human Leptin Monoclonal Antibody and Its Preliminary Application

Detection and its significance of serum leptin in children with juvenile rheumatoid arthritis

Resistin gene overexpression in adipose tissue of SD rats with high-fat diet and its correlation with leptin and insulin

Study of serum leptin level in patients with chronic obstructive pulmonary disease

The study of the relationship between leptin and early parenteral nutrition as well as growth of premature infants

The Correlation between Leptin and Microalbuminuria in Hypertensive Patients with Impaired Glucose Tolerance

Comparison of the relationship of serum resistive level and leptin level to plasma glucose level in patients with hypertension

Gene Expression of Fatty Acid Synthase in Subcutaneous Adipose and Its Relationship with Serum Leptin in Pigs

Serum leptin levels during pregnancy and its influences on gestational and postpartum weight

Relationship between Serum Leptin and Ventricular Hypertrophy, Blood Pressure in Primary Hypertension

Observation of the Concentration of Serum Leptin in Patients with Hypertrophic Cardiomyopathy

Relationships between serum leptin and nutritional status in patients with chronic obstructive pulmonary disease

The Relationship Between the Leptin Levels in Pregnancy-induced Hypertension Women and the Weight of Newborns

Measurements and Significance of Serum Leptin Concentration in Essential Hypertensive Patients

Serum Leptin Level and Its Significance in Chronic Renal Failure Hemodialysis Patients

Serum resistin and leptin in patients with chronic obstructive pulmonary disease and their relationship to nutritional state

The Experimental Study on the Relationship Between Insulin Resistance and Leptin Resistance and Hypertension with Obesity

Relationship between serum leptin level and malnutrition in patients with chronic obstructive pulmonary disease

The relationships of serum leptin concentrations to bone mineral densities in postmenopausal women with osteoporosis

Relationship between the levels of serum leptin and insulin resistance in patients with fatty liver

An Analysis for the Relationship Between Leptin, Inflammation and the Nutrition Status in Peritoneal Dialysis Patients

A study of relationship between serum leptin and obesity, diabetes mellitus related to antipsychotics

Relationship between Serum Leptin Level and Malnutrition in Patients undergoing Peritoneal Dialysis

Preliminary study of serum leptin level during middle and late pregnancy in Chinese

A preliminary study on the relationship between adiponectin, leptin and coronary artery lesion in impaired glucose tolerance rats

Relationship between the leptin concentrations in venous and cord bloods in pregnant women and the birth weight

Expression of leptin and leukemia inhibitory factor in the normal early gestation villi and gestational trophoblastic diseases

Peritoneal fluid leptin concentration and endocrine hormone in patients with polycystic ovarian syndrome

Relationship of Placental Leptin and Leptin Receptor mRNA Expression and Intrauterine Growth Retardation

The relationship between human plasma leptin and obesity as well as plasma insulin concentration

Influences of leptin receptor gene polymorphism and plasma leptin level on bone volume of patients receiving glucocorticoids

Advance in leptin regulation to body metabolism and its application in stockbreeding

The expression of leptin and leptin receptor in the human endometrium during the secretory phase

Relationship between serum leptin, free fatty acid and adiponectin receptors mRNA expression in white adipose tissues in obesity

Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals

Measurement of levels of maternal and umbilical blood serum leptin in hypertensive disorder complicating pregnancy

Effects of energy intake on plasma concentration of leptin and milk production in peripartum diary cows

Clinical Study on Relationship between Fat distribution and Leptin and Insulin in Acupuncture Treatment for Reducing Weight

Clinical significance of serum leptin measurement in patient with intrahepatic cholestasis of pregnancy

Examining consecutively serum leptin levels in normal pregnant and pregnancy-induced hypertension women

The effects of glucocorticoids and insulin on serum leptin level and its diurnal rhythmicity

Correlation between expression of leptin and clinicopathologic factors and prognosis in human gastric cancer

Leptin Protein Expression and Its Effect on Liver Fibrosis of Mice with Schistosomiasis Japonica

Study on the relationship between plasma leptin and clinical phenotypes in male patients with premature coronary heart disease

Changes of the circulating leptin levels and sexual development associated index in dietetic obese rats

Effect of Acupuncture on Leptin Resistance and Insulin Resistance in Simple Obesity Patients Complicated with Hypertension

Relationship between serum leptin concentration and nutritional status of patients with gastric cancer

The study of Zhen Wutang extract intervene experimental obesity and its effect on plasma lipids metabolism and leptin level

The Relationships between Dry Matter Intake and Plasma Leptin Concentration, Milk Production in Peripartum Diary Cows

The changes of leptin expression and its function in acute exacerbation period in the patient with COPD

A study of the relationship among serum leptin and the blood glucose and age in old men

Relationship between human serum leptin levels and obesity, blood pressure as well as serum uric acid

Correlation of Serum Leptin Levels with Nutritional Parameters and Respiratory Muscle Strength in Patients with COPD

Expression and localization of leptin and its receptor in submandibular gland of human fetus

Relationship between Serum Leptin Concentration and Serum Insulin Concentration in Patients with Type

Effects of Gender, Body Composition, and Fat Distribution on Serum Leptin Concentrations in Prepuberty Children

Effect of recombination human erythropoietin on serum leptin levels in maintenance hemodialysis patients

The Relationship between Leptin and Insulin Resistance in Essential Hypertensive Patients

Effect of high-fat-diet on serum glucose, triglyceride, leptin and insulin sensitivity in obesity-susceptible and obesity-resistant rats

Effects of high-permeable dialysis on serum leptin and nutritional status in maintenance hemodialysis patients

Comparison of Serum Leptin between Hypertensive Patients with Blood Stasis Syndrome Type and Non-blood Stasis Syndrome Type

An Analysis of the Relationship Between Serum Leptin and Nutritional Status in Patients with Lung Cancer

Development of a fluorescent quantitative RT-PCR assay for detection of expression of leptin mRNA

Correlation Between Obesity-Related Hypertension and Leptin Resistance

Effects of conjugated linoleic acid on growth performance, serum leptin and adiponectin in yellow feather broilers

Study on the relationship between children obesity and adiponectin, leptin, high-sensitive C-reactive protein

Clinical significance of serum leptin measurement in patients with acute myocardial infarction

A study on serum resistin and leptin levels and the relative factors in the patients with subcortical arteriosclerotic encephalopathy

Correlation between concentration of serum leptin and lipid in patients with essential hypertension

Influence of Rebamipide on leptin expression in gastric mucosa with portal hypertensive gastropathy

Expression and significance of leptin and its receptor in hepatic carcinoma