kinases

However, its structure may be similar to that of another class of enzymes called DNA-dependent kinases.

So people will try and get some sort of gene-based test to measure the expression-mutation of these kinases.

Kinases that work through different pathways, however, now seem to hold more potential.

We also describe recent advances in understanding how the regulatory protein kinases control the progress of the initiation reaction.

It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs).

Histidine kinases are widely existed in higher plants and are important components of two-component signal transduction systems.

Until now it was assumed that control of even distribution of chromosomes was only monitored by the checkpoint kinases in the kinetochore.

Tyrosine kinases from the vascular endothelial growth factor and epidermal growth factor receptor families are the most pursued targets.

Accordingly, the researchers have proved that these checkpoint kinases also exist alongside the centrosome and perform their function there.

Phosphorylation enzymes called protein kinases can attach a phosphate group to proteins that may be inactive enzymes.

Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions.

To fully exploit the potential of kinases as drug targets, novel strategies for the efficient discovery of inhibitors are required.

Mitogen-activated protein kinases mediate the oxidative burst and saponin synthesis induced by chitosan in cell cultures of Panax ginseng.

However, few tyrosine kinases have been shown to have a well-defined pathogenetic role in lymphomas .

Protein kinases comprise approximately 2 percent of the human genome, and are important anti-cancer drug targets.

SAP regulates signal transduction of the SLAM-family receptors by recruiting SRC kinases.

Protein tyrosine kinases have emerged as crucial targets for therapeutic intervention in cancer.

The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases.

The checkpoint kinases in cancer cells are frequently modified or present in incorrect quantity ratios.

Recent studies have revealed that the TAM receptor protein tyrosine kinases--TYRO3, AXL and MER--have pivotal roles in innate immunity.

The activity of cyclin-dependent kinases (CDKs) on specific targets mediates the temporal regulation of plant cell cycle transitions.

The action of BMP is mediated through receptor kinases and transcription factors called Smads that regulate the expression of target genes.

Casein kinases are critical in cell division and differentiation across species.

The largest group of kinases are Protein kinases, which act on and modify the activity of specific proteins.

DYRK1A is the first member of a novel subfamily of protein kinases with dual specificity.

However, developing such drugs has been hampered by lack of detailed understanding of how the Cdc25s fit with their associated kinases.

Inhibiting BCRABL tyrosine kinases can impede the growing progress of tumors.

In addition, because Sutent inhibits multiple kinases, it possesses activity against multiple types of tumors.

Kinases are protein switches that activate other proteins by adding a phosphate group to them via a process called phosphorylation.

Inhibiting BCR-ABL tyrosine kinases can impede the growing progress of tumors.

Progression through the cell cycle is regulated by cyclin-dependent kinases (CDKs).

Plants use receptor-like kinases (RLKs) to transduce extracellular signals into the cell.

Abnormal expression of aurora kinases usually lead to numerous abnormalities in cell mitosis.

Tyrosine kinases are involved in the pathogenesis of most cancers.

Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks).

This paper introduces the first, second and some new BCRABL tyrosine kinases inhibitors.

Both tasocitinib and Incyte's drug, INCB028050, target Janus kinases, which mediate signalling by immune-system proteins called cytokines.

But imatinib is known to cause heart problems in some people because it also switches off tyrosine kinases in the ABL family.

Effect of simvastatin on myocardial hypertrophy and expression of extracellular signal-regulated kinases in spontaneously hypertensive rats

Gene Expression and Activity Regulation of Two Calmodulin Binding Protein Kinases in Tobacco Seedling

A study of the protein tyrosine kinases pathway in human middle ear cholesteatoma

Protein kinases modulation of the cellular adaptations associated with opioid tolerance and dependence

Expression characteristics of phosphorylated forms of mitogen-activated protein kinases in hypertrophic scars

Effects of triptolide on the phosphorylation of epidermal growth factor receptor and its downstream MEK signal kinases in HaCaT cells

Apoptosis in hippocampal neurons and change of mitogen-activated protein kinases expression in rats with sleep deprivation

Extracellular signal-regulated kinases in the forming and maintaining of neuralgia in rats with chronic constrictive injury

Detection of intracellular phosphorylated protein tyrosine kinases by flow cytometry

Correlation between neck lymph node metastasis and focal adhesion kinases expression in oral squamous cell carcinoma

The regulated pathways of cyclin-dependent kinases inhibitors in vascular smooth muscle cell proliferation

Role of mitogen-activated protein kinases signal pathway in cardiomyocyte injury induced by serum after hypoxia and burn injury

Advances in mitogen-activated protein kinases signal transduction pathways and their effects on sepsis

The effects of chronic forced swimming stress on emotion and brain phospho-extracellular signal-regulated kinases in rats

Regulation Role of Reactive Oxygen Species and Mitogen-activated Protein Kinases in Plant Stress Signaling

Gene expression and change of stress activated protein kinases in fetal skin at different developmental stages

Role of mitogen-activated protein kinases in Myocardial Hypertrophy induced by hypertension

Protective action of inhibitors of protein tyrosine kinases on ventilator-induced lung injury

Effect of heat-stress-induced mitogen-activated protein kinases on activator protein-1 in vitro and its significance

Expression of extracellular signal-regulated kinases in autogenous vein graft

Effects of crosstalk between opioid receptors and MAP kinases on opioid tolerance and dependence

EGFR mutations and targeted therapy with tyrosine kinases inhibitors in non-small cell lung cancer

Protein Kinases and Environmental Stress Signaling Cascades in Plants

The role of mitogen-activated protein kinases family in ischemic preconditioning of rat heart

Senescence-induced Changes in Autophosphorylation Status and CatalyticActivity of Plasma Membrane Protein Kinases in Soybean Primary Leaves

Role of mitogen activated protein kinases in cerebral ischemic injury and the mechanism of modulation

Cloning and discrimination of protein tyrosine kinases in synovial cells

Cyclic Nucleotide Dependent Protein Kinases

Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases

Effects of lead on the activity of extracellular signal-regulated kinases in brain of mice

Review on the research development of small molecular protein tyrosine kinases inhibitors

Calcium-dependent protein kinases and the signal transduction of calcium ion in the plant

Research advances in receptor-like protein kinases of higher plants

Study on Protein Kinases Involved in Leaf Senescence and the Retarding Effect of Cytokinins

Phylogenetic Analysis of Receptor-like Kinases from Rice

Genesis of Tumor Vessels and the Related Receptor of Tyrosine Kinases

Recent Research Progress on Mechanism of AGC Family Kinases Activated by 3-Phosphoinositide-dependent Protein Kinase-1

Ca~(2 ) -calmodulin dependent protein kinases;

Syk Family of Protein Tyrosine Kinases

Studies on plant and wheat protein kinases