histone

In contrast to the universal nature of the DNA code, the histone language and its decoding machinery differ among animals, plants and fungi.

Genes can also be silenced by modification of the histone proteins that make up the "smart stuffing" in chromosomes.

These patterns are referred to as 'the histone code'.

Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome.

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.

The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.

Dr. Fischer's research shows that when young mice are learning, an acetyl group binds to a particular point on the histone protein.

A small molecule called an acetyl group attaches to a particular histone known as H4.

The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

DNA wraps around histone spools to form a rosarylike chain, which is then twisted into a bundle[ see illustration on opposite page].

RSEG is also able to incorporate a control sample and find genomic regions with differential histone modifications between two samples.

These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.

Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development.

Background: Histone acetylation as an epigenetic change is widely studied in cancer.

The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity.

The hypothesis of "Histone code" suggests an existing way of program information of eukaryotic gene control.

Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein.

Objective: To improve the synthetic procedure of the histone deacetylase (HDAC) inhibitor SAHA.

Covalent modifications of histone tails play a key role in the regulation of chromatin structure and control of transcriptional activity.

As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.

The canonical histone proteins are encoded by replication-dependent genes and must rapidly reach high levels of expression during S phase.

Some portions of the double stranded DNA were opened. The binding of histone to DNA was observed with molecular combing.

Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified.

Chromosome banding patterns are correlated with unique patterns of histone modifications.

DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling.

In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.

histone status renders DNA sequences accessible or inaccessible for transcription.

This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.

Covalent modifications to histone proteins play a critical role in regulating gene transcription.

Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.

The 146 bp of DNA wrapped twice around the core histone octamer are clearly visualized.

Histone lysine methylation plays a key role in the organization of chromatin structure and the regulation of gene expression.

The author introduced current knowledge of the mechanisms of histone H2B ubiquitination and its significance.

In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypo-acetylation.

In the histone code the methylation target is known as H3K9, where K stands for lysine.

The level of histone acetylation plays an important role in progression, proliferation and differentiation of leukemia.

To reverse the memory loss, doctors inject a compound called a histone deacetylase inhibitor.

Histone proteins both protect DNA and regulate genes as they combine with DNA to form chromatin.

Covalent histone modifications and ATP-dependent chromatin remodeling play important roles in the process of DNA repair.

Then specifc subtypes of nucleosomes are isolated with the aid of antibodies against particular histone variants.

Valproate acid, a histone deacetylases inhibitor, has been verificated to have anticancer effects in many studies.

SATB1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.

However, the repressive methyl groups on the H4 histone caused the arrays of nucleosomes to become significantly more compacted.

The good news clinically, said Munster, is that several existing compounds known as histone deacetylase inhibitorsdirectly target AKT.

The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC).

Each core histone exists in different variants partly as a result of posttranslational modifications such as methylation.

The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.

The invention relates to the inhibition of histone deacetylase.

HISTONE: Histones are crucial in the process of condensing and packing DNA within a cell's nucleus.

Histone lysine methylation plays a key role in epigenetic regulation.

Histones are proteins that regulate DNA packing, and histone deacetylases are enzymes that control the way those proteins work.

In prokaryotes the nuclear material is simply a circular strand of DNA, not complexed with histone proteins, and cell division is amitotic .

ObjectiveTo investigate the antitumor effect of MS275, a histone deacetylase inhibitor, on growth of the human myeloma cell line U266.

Conclusion APP expression on SH-SY5Y cells may increase through up-regulation of histone acetylation through P38MAPK pathway.

First, AOF1 does not appear to form stable protein complexes containing histone deacetylases.

Contrast to HMG histone H1 showed obvious inhibition effect on transcriptional activity of all of the rat liver nuclei.

The first part is studying on "Regulation of the Expression of Histone H3. 3 by Differential Polyadenylation" .

Recent data link changes in gene expression to chromatin remodeling, such as histone modifications and histone replacement.

Sensitive assay system for inhibitor screening and kinetic assays of HDAC1 (histone deacetylase 1).

Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).

At last, we propose a new model to interpret the process of DNA wrapping around histone.

Recently, research on histone variants is not only a new hotspot in epigenetics, but also a new annotation of "histone code" .

In addition to the MHC, this region on chromosome 6 also contains a cluster of histone genes.

Study of Expression Activity Acidic Non-histone in cell nucleolus of T-Lymphocyte Ag-Nors in Renal Transplantation Receptor

Advances in pharmacological study of histone deacetylase inhibitors

Relationship Between Histone Modifications and Gastrointestinal Cancer

Study of interactions between DNA and histone with molecular combing method

Mechanism of histone deacetylase inhibitors for treatment of hematological cancer and their clinical research

Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis;

Role of histone acetylation modification in posttranscriptional gene expression

Advances in combination therapies of histone deacetylase inhibitors with other antitumor agents

Molecular Mechanism of Plant Flowering Regulated by Histone Methylation

Molecular evolution of intron in histone genes in Drosophila melanogaster species group

DNA Methylation, Histone Modifications and Genes Silencing

Here's a video that animates the acetylation of histone proteins in the regulation of gene expression in cancer cells

Role of histone acetylation in the differentiation of human gastric cancer cell induced by DADS in vivo

The Relationship of DNA Methylation and Histone Methylation

The roles of histone lysine methylation in epigenetic regulation

Aberrant DNA Methylation and Histone Modification in Tumor

Brownian dynamics simulation of the interaction between DNA and histone

Development of Histone Methylation and Demethylation

Research Progress of Histone Methylation

The epigenetics of histone lysine methylation

Study on the Immunogenicity of Histone Derived from Tumor Cells

Covalent Modifications of Histone Tail

Effect of Human PMN on the Streptococcal Histone-Like Protein Release

Histone Variants and Histone Exchange

Effect of DNA methylation and histone decoration on tumor

A new target of cancer therapy: advances in the study of histone deacetylase

Effect of Trichostatin A on Histone Acetylation Level and Apoptosis in HL-60 Cells