There is very little difference between these two words, but distrust is more common and perhaps slightly stronger. If you are sure that someone is acting dishonestly or cannot be relied on, you are more likely to say that you distrust them. If you are expressing doubts and suspicions, on the other hand, you would probably use mistrust.这两个词意义差别很小，但 distrust 更通用，或许语气稍强。确信某人不诚实或不可信较常用 distrust，而表示猜疑、疑虑、不信任则大概要用 mistrust。
dis·trustBrE/dɪsˈtrʌst/NAmE/dɪsˈtrʌst/verbpresent simple - I / you / we / theydistrustBrE/dɪsˈtrʌst/NAmE/dɪsˈtrʌst/present simple - he / she / itdistrustsBrE/dɪsˈtrʌsts/NAmE/dɪsˈtrʌsts/past simpledistrustedBrE/dɪsˈtrʌstɪd/NAmE/dɪsˈtrʌstɪd/past participledistrustedBrE/dɪsˈtrʌstɪd/NAmE/dɪsˈtrʌstɪd/ -ing formdistrustingBrE/dɪsˈtrʌstɪŋ/NAmE/dɪsˈtrʌstɪŋ/~sb/sthtofeelthatyoucannottrustorbelievesb/sth不信任；怀疑◆Shedistrustedhismotivesforwantingtoseeheragain. 她怀疑他想再见她一面是别有用心。distrust / mistrust
There is very little difference between these two words, but distrust is more common and perhaps slightly stronger. If you are sure that someone is acting dishonestly or cannot be relied on, you are more likely to say that you distrust them. If you are expressing doubts and suspicions, on the other hand, you would probably use mistrust.这两个词意义差别很小，但 distrust 更通用，或许语气稍强。确信某人不诚实或不可信较常用 distrust，而表示猜疑、疑虑、不信任则大概要用 mistrust。