Tiredness can cause a worsening of symptoms.疲劳可能会导致症状恶化。

This latest incident is bound to lead to a further worsening of relations between the two countries.这一最新事件肯定会导致两国关系进一步恶化。

They remain stranded in freezing weather and rapidly worsening conditions.他们仍然受困于严寒的天气和迅速恶化的环境。