(in American football)to clear the way for the player with the ball by blocking players from the other team掩护阻挡（为己方持球队员让出道路）Topics Sports: ball and racket sportsc2
(informal)to help somebody by dealing with problems for them so that they do not need to deal with them（为帮助某人）积极介入
You have plenty of friends that can always run interference for you.你有很多朋友可以随时为你进行干扰。