It can be confused with essential mixedcryoglobulinemia.
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For example, certain macroglobulins tend to precipitate within blood vessel with cold, a phenomenon known ascryoglobulinemia.
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House notices that the patient's blood thickens dangerously when his body temperature drops (cryoglobulinemia), something that can not be faked.
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Other causative conditions include infections, toxicities, antiphospholipid syndrome,cryoglobulinemia, neoplasms.
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This example is from Wikipedia and may be reused under a CC BY-SA license.