spindle checkpoint

collocation in English

meaningsofspindleandcheckpoint

These words are often used together. Click on the links below to explore the meanings. Or,see other collocations withspindle.
spindle
noun[C]
uk
/ˈspɪn.dəl/us
/ˈspɪn.dəl/
a part of a machine around which something turns, or a rod onto which thread is twisted when it is spun (= made ...
See more atspindle
checkpoint
noun[C]
uk
/ˈtʃek.pɔɪnt/us
/ˈtʃek.pɔɪnt/
a place where people are stopped and asked questions and vehicles are examined, especially at a border between ...
See more atcheckpoint

(Definition ofspindleandcheckpointfrom theCambridge English Dictionary© Cambridge University Press)

Examplesofspindle checkpoint

These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
Meiotic spindle andspindlecheckpointproteins are responsible for normal chromosome alignment and separation during meiosis.
From theCambridge English Corpus
It is involved in microtubule attachment to chromosome centromeres and in the activation of thespindlecheckpointduring mitosis.
From
Wikipedia
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During this process, kinetochores that are attached to the mitotic spindle but that are not under tension trigger thespindlecheckpoint.
From
Wikipedia
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Once activated, thespindlecheckpointblocks anaphase entry by inhibiting the anaphase-promoting complex via regulation of the activity of mitotic checkpoint complex.
From
Wikipedia
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Shugoshin also acts as aspindlecheckpointcomponent.
From
Wikipedia
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Impairedspindlecheckpointfunction has been found in many forms of cancer.
From
Wikipedia
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This situation generates centromeric tension, and for this reason thespindlecheckpointis not activated.
From
Wikipedia
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Upon microtubule-kinetochore attachment, a mechanism of stripping via a dynein-dynein motor complex transportsspindlecheckpointproteins away from the kinetochores.
From
Wikipedia
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Such a signal creates the mitoticspindlecheckpoint.
From
Wikipedia
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During mitosis or meiosis, thespindlecheckpointprevents anaphase onset until all chromosomes are properly attached to the spindle.
From
Wikipedia
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Thespindlecheckpointsystem is a regulatory system that restrains progression through the metaphase-to-anaphase transition.
From
Wikipedia
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An unattached kinetochore, and thus a non-aligned chromosome, even when most of the other chromosomes have lined up, will trigger thespindlecheckpointsignal.
From
Wikipedia
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Key tumor suppressors such as p53 also play a role in thespindlecheckpoint.
From
Wikipedia
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Both the monotelic and the syntelic configurations fail to generate centromeric tension and are detected by thespindlecheckpoint.
From
Wikipedia
This example is from Wikipedia and may be reused under a CC BY-SA license.
These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors.
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See other collocations withspindle