Fibroblast growth factor(FGF-1)lacks amino-terminal signal peptide, so it can't release through the classical endoplasmic reticulum(ER)-Golgi pathway.

ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD).

FGF-1 is involved in many pathological processes, so the measures to disturb or inhibit FGF-1 release pathway provide a new strategy for the diseases directed by FGF-1.