CHIP, an E3ubiquitinligase and cochaperones, involves in energy metabolism and protein quality control.
CHIP属于连接酶类，具有E3泛素连接酶活性，参与能量代谢途径和新陈代谢。
2
The regulatory step affected by phosphorylation could involve either recognition of the substrate by an E3ubiquitinligase or the actual conjugation reaction.
由磷酸化影响的调控步骤可能与E3泛素连接酶对底物的识别有关，也可能与实际的交联反应有关。
3
The breast cancer susceptibility gene, BRCA1, codes for an E3ubiquitinligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair.