The knoevenagel condensation of aromatic aldehydes with ethylcyanoacetate proceeds smoothly in the presence of potassium fluoride giving products in high yield.
在氟化钾催化下， 芳香醛与氰乙酸乙酯发生克脑文格尔缩合反应，得到高产率的缩合产物。
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The knoevenagel condensation of aromatic aldehydes with ethylcyanoacetate proceeds smoothly in the presence of potassium fluoride giving products in high yield. Only the E isomers could be isolated.
METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethylcyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.