When renal function declined, drugexcretion slow, and drug metabolism altered.
肾功能减退时，不但药物排泄缓慢，而且药物代谢也会发生改变。
2
The main two mechanisms of FQs resistance in enterococci are alterations in the targets of FQs and decreased intra-cellular drugs accumulation resulting from active excretion of drug.
肠球菌对氟喹诺酮类抗菌药的耐药机制主要为靶位改变和药物主动外排导致的细胞内药物积聚减少。
3
Some authors have reported that the use of this drug results in increased urinary excretion of an amyloid-like substance both in mice and man, but others have failed to confirm this.