The conditions for the analysis of transformed products of 3-cyanopyridine via microorganism by RP-HPLC with flow rate gradient of mobile phase have been studied.
本文研究了3-氰基吡啶微生物转化产物的反相高效液相色谱（RP-HPLC）分析方法。
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4-cyanopyridine, intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in a fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.