Fluid shear is the mechanical force exerted by the movement of fluids over cell surfaces and has been found to play an important role in cellular differentiation, development and function.

Such models offer exciting new insights into cell proliferation, differentiation and immune function, and are providing a platform to understand normal tissue homeostasis and transition to disease.

There is overwhelming evidence that the tumor clone including brain tumor is heterogeneous with respect to both morphology and function, which indicates differentiation potential of tumor stem cells.