Pathological changes of the organization, mainly the epidermal cuticle significant parakeratosis, acanthosis cell layer thickening, epidermal sudden downward extension of in-depth dermis.

Due to the good biocompatibility of this membrane, the cuticle cell of human can be cultivated in it, also the capillary vessel and the fibroblast can grow in it.

The cuticle of Whangkeumbae was relatively thin, and the epidermis cells were few, discontinuous, even not existing. The cell included less tannin materials under the epidermis.