The anticancer mechanism of nitrosoureas is very similar to the carcinogenic mechanism, both of them can alkylate DNA bases and form DNAcross-linking further.
亚硝基脲的抗癌与致癌机理是非常接近的,都能够使DNA碱基发生烷化,进一步形成DNA股间交联。
2
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNAcross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
Scientists have known that the protein complex known as FANCI-FANCD2 responds to DNA damage and repairs cross-linking, but the details of how the complex works have been unknown.