High living, including a dependence on painkillers like morphine, helped bring her a bleeding ulcer and liver damage; more than once she collapsed dramatically onstage.
高压的生活再加上对吗啡等止痛药物的依赖，导致她患上了出血性胃溃疡和肝损害。
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Objective To investigate the changes in CREB-1 protein expression in three brain regions induced by acute or chronic morphinedependence and withdrawal.
Conclusion morphine may affect purine nucleotide metabolism of nerve cells, increase the adenylate and adenosine levels, which may be one of the mechanism of morphinedependence and tolerance.