The doselimitingtoxicity ssociated with this regimen was myelo suppression with grade 3~4 neutrocytopenia in 72 % of patients.
本化疗方案的剂量限制毒性为骨髓抑制,其中72 %的病人发生3~ 4度中性粒细胞下降。
2
The doselimitingtoxicity (DLT) of it was neutropenia and diarrhea. Its maximum tolerance dose (MTD) may be reduced by elevated liver or kidney function.
其剂量限制毒性(DLT)为中性粒细胞减少和腹泻,肝肾功能下降会降低最大耐受剂量(MTD)。
3
While we have not seen dose-limitingtoxicity at this level with the slower infusion (without pre-medication), we have seen headache in two patients, which is a moderate adverse effect.