Founder mutations are a class of disease-causing genetic mutations, each derived from its own ancestral "founder" in whom the mutation originated.
创始者突变是一类引起疾病的基因突变，每一种都源自其自身祖先的“创始者”。
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While most disease-causing mutated are found in humans at a rate of one in a few thousand to one in a few million people, founder mutation can occur at much higher rates.
虽然大多数致病突变在人类中发现的概率为千分之一到百万分之一，但基础突变发生的几率可能高得多。
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When this water is used for agricultural irrigation, farmers risk absorbing disease-causing bacteria, as do consumers who eat the produce raw and unwashed.