For companies with already high payout ratios, this can be problematic, as a higher percentage of earnings paid to shareholders may crimp capital expenditures or research and development commitments that are needed to keep the business growing.

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Peter Appelbaum, an expert in resistant bacteria at Penn State, says the drug has been in development for 15 years and causes more nausea than other drugs--a side effect that could crimp Wyeth's rosy forecasts.

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