Because cases of new and worsening congestive heart failure have been reported with certolizumab therapy, patients with heart failure should be treated with caution and monitored carefully.

Conclusion Regional nerve blockade may be a feasible, safe and effective treatment for congestive heart failure patients who do not respond well to the existing optimal medical therapy.

Objective to investigate cardiac function improvement with titrated controlled-release metoprolol therapy in the patients of chronic congestive heart failure (CHF).