OBJECTIVE To develop a RP-HPLC method for the determination of clonazepam (CZP) in serum of drug-dependent patients to provide a scientific basis for clinical use of CZP.
目的建立测定药物依赖症患者血清中氯硝安定（CZP）浓度的RP—HPLC法，为临床用药提供依据。
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In repeated dose decreasing group, the CZP concentration ratio in both brain and serum declined to 0.7 with the dose decrease, almost the same as that of single-dose group.
Objective To explore the effect of clonazepam (CZP) on background EEG activities and epileptiform discharges, and the relationship between the effects and the serum drug concentration.