Cigarette smoking induces CYP1A2 and may, therefore, enhance the conversion of clopidogrel to its active metabolite.
吸烟诱导CYP1A2而且可能因此增强氯吡格雷转化为其活性代谢产物。
2
Cytochrome P4501A2 (CYP1A2) plays a critical role in the oxidative metabolism of a variety of exogenous compounds such as drugs, environmental procarcinogens and other xenobiotics.
细胞色素氧化酶p 4501a2 (CYP1A2)在药物代谢、前致癌物激活的过程中起重要的作用。
3
On the other hand, many commonly used drugs, including furafylline, fluvoxamine, quinolone antibacterial, agents verapamil, cimetidine and oral contraceptives, can inhibit CYP1A2 activity.