Constitutive activation of the pathway involving these two genes appears to be a major contributor to the development of uveal melanoma. (Funded by the National Institutes of Health and others. ).

The orientation of orientation offense is the subjectively mental needs which can not influence the harmfulness and extent of dangerous act, so it can not be token as the constitutive element.

The rationality of the principle of presumptive fault liability of employers can be deduced from the determination of the constitutive requirements as well as the arrangement of liability bearing.