In addition, the paper reviewed screening methods for differentiation inducers, DNAtopoisomerase inhibitors, antimicrotubule drugs and biological response modifiers.
还对分化诱导剂、拓扑异构酶抑制剂、抗微管药和生物反应调节剂的筛选方法进行了评述。
2
Purpose to investigate the relationship between DNAtopoisomerase and cell proliferation, apoptosis in ovarian carcinomas.
目的:探讨DNA拓扑异构酶在卵巢浆液性、黏液性囊腺癌中的表达及与细胞增殖、凋亡的关系。
3
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).