Primary biliary cirrhosis (PBC), which is an early form of liver cirrhosis, is a long term progressive autoimmune disease, in which environmental factors are thought to play a part.

Newborn pigs lacking CFTR showed defective chloride transport and developed meconium ileus, exocrine pancreatic destruction, and focal biliary cirrhosis, which are all hallmark of CF disease.

To explore the correlation of adenine nucleotide translocator 3(ANT3) gene expression level with primary biliary cirrhosis(PBC).