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1 ?阿司咪唑 阿司咪唑上市后心血管系统安全性评价 关键词：阿司咪唑；心脏毒性；上市后药物安全性监测 [gap=508]Key words：astemizole；cardiotoxicity；post marked monitoring of drug 2 ?息斯敏 服一片息斯敏(Astemizole)或扑尔敏，很快就会恶化。一晃神，一转眼．我们就这样垂垂老去． 头痛(Headache)： 原故可以是慢性鼻炎、呛水或身段严寒、暂时... 3 ?阿斯咪唑 另一个药物为在临床上曾广泛使用的阿斯咪唑(Astemizole),阿斯咪唑虽无中枢的镇静作用,但与其他药物有严重的相互作用和具有心脏毒性,99年被撤销. 4 ?抗组胺药 会馆医生说,如果是过敏性鼻炎,可服用一般的抗组胺药(Astemizole),(Phenergan),,而如果是鼻窦炎,就要服用抗 ..
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METHOD Recording the ECG of mice in different time after they were admistrated with astemizole in different dose in different time. 方法用不同剂量的阿司咪唑对小鼠灌胃，分别记录不同时间的心电图变化。 - 2
CONCLUSION: the effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole. 结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。 - 3
RESULTS astemizole could slower the heart rate of mice, prolong P-R and Q-T interphase, even arise the complete AV block and sinus beat stop with the dose increase. 结果阿司咪唑使多数小鼠心率减慢，P R间期和Q T间期延长，随剂量增加，甚至可引起完全性房室传导阻滞和窦性停搏。
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