Chemicalcarcinogenesis is involved in complicated multiple stages of initiation, promotion and progression.
化学致癌过程是涉及启动、促进和进展等多阶段的复杂过程。
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METHODS: Initiation and promotion two-stage chemicalcarcinogenesis method was used to induce cutaneous tumors in the mouse back skin.
方法：采用启动和促进两阶段化学诱癌方法在小鼠背部诱导皮肤肿瘤；
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Conclusion COX-2 overexpression occurred in the early stage of oral carcinogenesis, it could be an important target for the chemical prevention and therapy.