Objective: to understand the changes in hematopoietic growth factor receptors during erythroid differentiation of pluripotent cells.
目的:了解多潜能造血祖细胞向红系分化过程中造血因子受体的改变。
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The absence of ALAS2 leads to maturation arrest of primitive erythroidcells. Heritable mutations of ALAS2 gene are responsible for the human X-linked sideroblastic anemia (XLSA).
Methods Induce the differentiation of erythroleukemia cell line HB60-5 to mature erythroidcells by altering the culture condition and plot a cell growth curve.