The 7-bromo group was replaced with various aniline, and then treated with 4- methoxybenzenesulfonyl chloride to afford the 6-azaindole-1-sulfonamides.
Structure- activity relationship information revealed that 7-aryl-6- azaindole-1- sulfonamide derivatives was more potent than 7-anilino-6-azaindole-1- sulfonamide derivatives.