Some neoplastic cell nests have peripheral palisading, and some cells form cord-like structure between collagenous connective tissue.

Stimulation of the cell metabolism by MPS leads to an increased formation of important constituents of connective tissue, thus resulting in an increased skin moisture and elasticity of the skin.

Hepatic histopathological examination showed proliferation of bile duct and fibrous connective tissue, obvious increase of hepatic cell oncosis and liver cell cord derangement in BDL group.