The loss of cell-celladhesion is a common event in nearly all epithelial malignancies and is associated with increased cellular invasiveness and metastasis.
失去细胞与细胞间的粘附是几乎所有上皮细胞癌的共同特点,并且伴随着细胞侵袭力和转移能力的升高。
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AJs are formed when nectin assembles cadherin at the cell-celladhesion site and these junctions are then involved in the formation and maintenance of TJs (4, 5).
Integrins are an important cell surface molecules that contribute to a variety of biological functions, including mediate cell and extracellular matrix and cell-celladhesion.