Thus, the NEU-induced primary chromosomebreakage may not be repaired by the ligase.
由NEU所诱发的染色体初级断裂不能为连接酶所修复。
2
Rearrangement — Chromosomebreakage followed by reconstitution in an abnormal combination. If unbalanced, the rearrangement can produce an abnormal phenotype.
染色体结构改变造成遗传物质的重新排列。若为非平衡型重排，则可导致异常表型。
3
Cells from at patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosomebreakage (3, 4).