Taxol can inhibit mitosis of the microtubule network renewable, prevent mitotic spindle lead to the formation of chromosomebreak, inhibit the replication of tumor cells.
Otherwise, the chromosomebreak and rearrangement induced by radiation maybe play important pole in leading to the translocation and misalignment of cancer genes and other correlated genes.
另外,辐射所致染色体的断裂和重排对癌基因和其他相关基因的移位和失调可能起着重要作用。
3
Structurally, the aberrations of the chromosome-type break, chromatid break, double minute chromosome were also remarkably different (P<0.01).