Summary of Background Data. Recently we described an IVD degeneration model in the goat by injecting chondroitinase ABC. This results in mild progressive disc degeneration.
Objective:To investigate the effects of chondroitinase ABC on chondroitin sulfate proteoglycans(CSPGs) and growth associated protein-43(GAP-43)after spinal cord injury in rats.
Objective. Simulate the reduced glycosaminoglycan content and altered mechanics observed in intervertebral disc degeneration using a controlled injection of chondroitinase ABC (ChABC).