Progressively earlier symptom onset and increasing symptom severity in this family is consistent with geneticanticipation which has not been previously reported in SPG3A-HSP.
家系中越来越早的发病和症状加重与遗传早现相一致，这在SPG3A-HSP中尚属首例。
2
The mutant heteroplasmy levels are positively associated with genetic relationship, seizure anticipation, plasma lactate data and other clinical features.