三氯乙醛
2-Alkyl-4,4,4-trichloro-2-butenals was obtained via dehydration of the aldol products prepared through direct cross-aldol reactions of chloral with aliphatic aldehydes at first. The asymmetric bioreduction of thisα,β- unsaturated aldehyde was next studied in detail.
首先通过三氯乙醛与丙醛、正丁醛的交叉缩合反应合成了羟醛缩合产物,然后将其脱水得到2-烷基-4,4,4-三氯-2-丁烯醛,之后对这种α,β-不饱和醛的面包酵母催化不对称还原反应进行了系统的研究。