ABSTRACT Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs.
天然抗生素结构的适当修饰可改善其性能，是探索开发新的有效途径之一。
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Mechanisms of antibiotics resistance includes: (1) target site modification; (2) production of inactive enzymes; (3) decrease of drugs penetrance; (4) expression of efflux pumps.
抗菌药物耐药机制包括：(1)靶位修饰；(2)产灭活酶；(3)药物渗透力下降；(4)外排泵表达。
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Ingenious modification of structure of natural antibiotics could improve their properties, which is one of ways to search for new drugs.