Conclusion (1) The abnormal high expression of peripheral blood costimulatorymolecules CD28 suggested CD28 disorder may play an important role in immuno pathogenesis of CAA.
The results show that the four co-stimulatorymolecules anticipate the egg granuloma formation. Especially the effect of B7-2 and CD40 molecules are more significant.
CD80 is one of the co-stimulatorymolecules binding CD28, which binds CD28 on the surface of t cells to provide second signal for efficient activation of t cells.