CD80 is one of the co-stimulatory molecules binding CD28, which binds CD28 on the surface of t cells to provide second signal for efficient activation of t cells.
The results show that the four co-stimulatory molecules anticipate the egg granuloma formation. Especially the effect of B7-2 and CD40 molecules are more significant.
No statistically significant difference in the expression levels of co-stimulatory molecules on dendritic cells surface between the groups immunized with DNA vaccine alone or with TLRs.