Within two centuries, European diseases and Spanish ships had driven the Calusa from Sanibel.
BBC: Florida??s stunning island sanctuary
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But the formidable native Calusa tribe, who had already been there for 2, 500 years, did not take kindly to the invasion.
BBC: Florida??s stunning island sanctuary
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Learn about the history of the island at the Sanibel Historical Village and Museum where seven buildings have been restored to their original condition to help tell the stories of the Calusa, the early Spanish and the pioneer families who farmed here in the 1800s.