Methods:Bicalutamide was prepared from 4-cyano-3-(trifluoromethyl) aniline and 2-methylacryloyl chloride by four steps: acylation, cyclization, substitution, and oxidization.
Results besides the action of conduction anesthesia chlordimeform has the cardiovascular toxicity and the antiarrhythmic action induced by barium chloride parallel to26-dimethyl aniline.
4-chloro-2-trifluoromethyl aniline was synthesized from 2-trifluoromethyl aniline, using hydrochloric acid-hydrogen peroxide as the chlorination agent and cupric chloride as the catalyst.