OBJECTIVE To investigate the brain pharmacokinetics of tetramethylpyrazine hydrochloride (TMPH) after intranasaladministration in rats.
目的研究盐酸川芎嗪(TMPH)经大鼠鼻腔给药后的脑内药动学特性。
2
AIM To study the feasibility and possible action mechanism of the treatment of cerebrovascular disease with intranasaladministration.
目的:探讨鼻腔给药治疗脑血管疾病的可行性和可能的作用机制。
3
Nasal administration also has specific immune properties. In this paper, the advances in studies on status and preparation of intranasal drug delivery are reviewed.