AIM: To screen and identify the short-peptide which specifically bind to human CD59 so as to design short-peptide clamp with counteracting tumor escape activity.

Conclusions: HIFU treatment could reduce the expression of local immunosuppressive factors. It would be helpful to the recovery of the balance between host antitumor immunity and tumor escape.

It may be one reason for immune escape of tumor cells that induces the development and metastasis of tumor.