?什麽事

... It's about my grandfather. 是关于我爷爷。 What's the problem? 什么事 It won't sound like a big deal, 这事听起来没啥严重 ...

?是什麽问题

很高兴佑帧 What's the problem? 是什么问题 Come on! You'll hear about it.

?怎么了

... mobile phone 手提电话,手机 What's the problem 怎么了 fat a. 肥胖的; n. 脂肪 ...

?什麽问题啦

这正是我想要跟 谈谈的 Susan What's the problem? 什么问题啦 Marilyn's career. Marilyn的事业。