The output of genome-wide association studies is vast, yet it is rarely straightforward to identify the functional connection between a variant and a disorder.

The stress of main memory is abated, the times of scan of database are cut down, and the algorithm executes more efficient mining of association rules in time-variant database.

Statistical analysis established that "no single genotyped variant is responsible for the association in the upstream region of TNFSF4, " Dr. Vyse and colleagues report.