Scattering on other regions of the molecule there were 10 single aminoacidsubstitutions, which could be explained as site-mutations of the gene.
此外，尚有10个氨基酸替代散在于分子内其它区域，这种替代是由于基因突变造成的。
2
DNA sequence revealed that 4-186 contains two aminoacidsubstitutions, K167R and S374C, both of which locate neither the substrate - binding sites nor the metal - binding sites of EAP.
If protein evolution is due in large part to slightly deleterious aminoacidsubstitutions, then the rate of evolution should be greater in proteins that contribute less to individual fitness.