For example, vandetanib can cause serious ventricular arrhythmia leading to sudden death.
FORBES: Is the FDA Approving Drugs Too Quickly?
2.
Because vandetanib affects the electrical activity of the heart, potentially lethally, it is being sold under a Risk Evaluation and Mitigation Strategy (REMS).
FORBES: AstraZeneca's Victory Highlights Difficulty Of Cancer Drug Development
3.
Vandetanib, the drug approved today, failed in non-small cell lung cancer and in bladder cancer before it proved effective in medullary thyroid cancer.
FORBES: AstraZeneca's Victory Highlights Difficulty Of Cancer Drug Development