It's nearly impossible to achieve and maintain a high-alkaline pH for a prolonged period of time.

They are able to protect a protein drug such as insulin from the acidic pH of the stomach and then release it in the more alkaline pH of the intestine.

We found that bovine serum albumin was accumulated by chordoma cells from the incubation media, and this accumulation depended on extracellular pH, with the highest accumulation at alkaline pH.