In the super early phase of acute cerebral ischemia, many therapeutic drugs cannot penetrate into the complete blood-brainbarrier (BBB) and enter brain tissues within the effective time window.
Aim to synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the bloodbrainbarrier (BBB).
目的制备盐酸他克林(THA)的酰化前体药物以提高其透过血脑屏障(BBB)的能力。
3
The increase of blood-brainbarrier (BBB) permeability is a key link in causing the pathological changes in vasogenic brain edema and inflammatory reaction.